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Comprehensive chemical-toxicological research of copper(II) sulfate solutions containing reduced glutathione

E. I. Lyalina, A. I. Fokina, T. Ya. Ashikhmina, A. S. Olkova, E. V. Beresneva, L. V. Darovskikh, A. S. Yarmolenko

Раздел: Экотоксикология

The composition and toxicological properties of copper(II) sulfate solutions containing reduced glutathione (GSH)have been studied. It was found that complex compounds Cu2+ with GSH are formed in the solution in the Cu(II):GSH molar ratios 1:1, 1:2, 1:3, 1:4. Simultaneously with the formation of complexes in solutions, oxidation-reduction reactions occur, accompanied by the formation of active forms of oxygen and oxidized glutathione (GSSG). All the described processes lead to a decrease in the active concentration of Cu2+. The toxicological properties of solutions with a molar ratio of Cu(II):GSH 1:1, 1:2, 1:4 were determined. For this purpose, test objects of different systematic accessory were used: cyanobacterium Nostoc linckia 271, crustaceans Daphnia magna Straus, infusoria Raramecium caudatum Ehrenberg and bioassay “Ecolum” . The chemical composition of solutions was correlated with toxicity. Reduced glutathione has a protective effect on daphnia, which is most pronounced in the variant 1Cu(II):4GSH. However, the level of viability of cyanobacteria, in contrast to hydrobionts, decreases in the 1:1 → 1:2 → 1:4 range. The decrease is due to the bioaccumulation of copper, which increases with the increase in the fraction of reduced glutathione. Such an effect may be formed by complex compounds, which is consistent with the literature data. For D. magna, such a relationship is not observed, the resulting compounds and reduced glutathione do not affect the accumulation of metal.

Ключевые слова: reduced glutathione, copper(II) ions, bioassay, active forms of oxygen

Статья опубликована в № 2 за 2018 год
DOI: 10.25750/1995-4301-2018-2-101/2-107/1