The aim of our study is to estimate the efficiency of using functional food supplements enriched with blueberry (Vaccinium uliginosum L.) powder to reduce carbon tetrachloride intoxication manifestations. The influence of the inclusion of
dried blueberries on the indicators of protein metabolism, as well as food products based on bread and cottage cheese with
the dried blueberries in their recipe, was investigated. Those parameters were evaluated by the content of total protein,
medium molecular peptides, De Rittis coefficient and oxidative balance (assessed by the content of TBA-active products,
ascorbic acid and total antioxidant activity index) in the blood plasma in rats intoxicated with carbon tetrachloride. The
biological effect of including blueberry powder was achieved by replacing an equivalent part of the standard vivarium
diet with dried blueberries, white bread and cottage cheese enriched with blueberry powder for 14 days. All animals were
divided into twelve groups, six of which remained intact and six were simulated total body intoxication by subcutaneous
injection of 66% tetrachloromethane solution. The control group consisted of animals kept on a standard vivarium diet.
It has been established that the addition of blueberries to the diet both in a free form and as a part of the functional foods
has a significant positive effect on the metabolism. It is confirmed by studying the protein exchange state (increasing
values of total protein and decreasing of average molecular peptides) and the oxidant balance (decreasing the concentration of TBA-active products, increasing of ascorbic acid and total antioxidant activity). Inclusion of blueberries in the diet
during the introduction of carbon tetrachloride significantly reduces the severity of intoxication, which was expressed in
higher values of De Rittis coefficient and lower concentration of medium molecular peptides and TBA-active products.
Using enriched cottage cheese is the most effective way to reduce the manifestations of intoxication. It is confirmed by
changes of indicators’ level in comparison with the vivarium ration group: the De Rittis coefficient is increased by 39.6%
(p < 0.001), total protein – by 39.8% (p < 0.001), ascorbic acid – by 3.12 times, total antioxidant activity – by 29.6%
(p < 0.001). The indicators of average molecular peptides are decreased by 19.1% (p < 0.001), TBA-active products – by
35.2% (p < 0.001).
ISSN 1995-4301
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