The partial replacement of antibiotics with biologically active substances at treatment of cows’ mastitis
M. A. Aziamov
Section: Social ecology
The World Health Organization (WHO) is informing about the antibiotic resistant strains of Staphylococcus aureus
increasing problem. These bacteria are changing their genomic composition under the influence of antibiotics and are rapidly
spreading in the environment, threatening human health and food security in a number of countries. WHO requires reducing
the use of antibiotics in cows’ mastitis by 50%. Staphylococcus aureus is the prevailing kind of cows’ mastitis pathogen in
Western Europe and Russia. The staphylococcal mastitis caused by multiresistant strains of Staphylococcus aureus is registered
in almost 90% of large farms and complexes where antibiotics are used.
The possibility of partial replacement of antibiotics with biologically active substances at treatment of clinical mastitis in
cows was evaluated. It is established that Interferon bovine recombinant, Polysaccharide of Hericium erinaceus fungus (PS of
H. еrinaceus) and Dialderon after 10 days of treatment of clinical mastitis in cows increased the amount of cured individuals,
respectively, by 30, 20 and 20% in comparison with antibiotic therapy. Biologically active substances normalized the number of
somatic cells in milk to physiological level. The studied substances reduced the levels of interleukin-2 (Il-2) and interleukin-8
(Il-8), prostaglandins E2, normalized erythrocyte sedimentation rate (ESR) and phagocytic activity in the blood of experimental
animals. The somatic cells number in the milk of experimental groups cows are decreased to physiological norm after
10 days of treatment. Milk after treatment of cows was fit for food consumption 72 hours earlier than with antibiotic therapy.
ISSN 1995-4301
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