This study was conducted on the territory of the city of Kazan with the dominant aerogenic flow of metals from a significant number of stationary and mobile sources of pollution, causing specific and non-specific responses in the population. Use of modern mathematical methods, ways of assessment of a response of biological objects to anthropogenic influence, chemical analysis researches of content of metals allowed to allocate sources and to determine threshold concentration of metals in urboekosistema components Wednesdays, by the upper bound of acceptable concentration in biosubstrates of teenage children. As a result, we have proposed and tested a methodology for calculating threshold concentrations of essential and toxic metals in snow cover and soils of Kazan, which do not lead to an increase in their regional reference values in the blood and hair of adolescent children.