Mouse-modeled change in the toxicity of manganese(II) ions when using activated carbons
O.M. Plotnikova, A.V. Sharov
Section: Ecotoxicology
The content of manganese ions (Mn2+) in the rivers and lakes of the Kurgan region (Russia) reaches 3–6 mg/L, reaching 10 mg/L and more in winter, which is significantly higher than the permissible concentrations. The article presents the results of studying the effect of Mn2+ ions on the blood biochemical parameters of three generations of laboratory mice after drinking solutions containing Mn2+ ions (20 mg/L). In mice of the first generation, an increase in the products of lipid peroxidation (LPO) by 1.4 times was observed while the activity of aminotransferases decreased by 20–30% and carbonyl protein products (CPB) by 15–25%; in the 3rd generation, Mn2+ -induced protein oxidation increased, as the aldehyde and keto derivatives increased 1.4 and 1.7 times, aerobic processes of glycolysis were activated, which was accompanied by a decrease in lactate and glucose and an increase in urea.
The waviness of the effect of Mn2+ ions on chronic exposure is noted – the effect in the first and third generations is more intense than in the first.
And also assessed the possibility of using activated carbons obtained from birch wood (AC) for cleaning from water from excess Mn2+ ions. Synthesized in the course of the study, ACs are characterized by high adsorption activity: the specific surface area is 560 m2/g, the pore radius is 2–7 nm, the amount of hydroxyl and carboxyl groups is 0.8–0.9 mmol/g. The number of Mn2+ ions on the surface of the AC was 0.60 mmol/g (calculated from the adsorption isotherm of the manganese sludge solution). The biochemical blood parameters of mice were determined after oral administration of a solution containing Mn2 + ions (20 mg/L) and after oral administration at a dose of 7.5 μmol/g Mn2+ ions, as well as extracts from AU with adsorbed Mn2+ ions. The extract from AU with adsorbed Mn2+ ions increased lipid and protein oxidation products and the activity of aminotransferases 1.3–1,4 times, the amount of urea 1.7 times, and the solution in the maximum dose of Mn2 + - POL and reduced the level of keto-derived proteins.
ISSN 1995-4301
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