Early and remote effects of gamma irradiation and uranyl nitrate in the liver lipids of mice
А.G. Kudyasheva, N.G. Zagorskaya, L.N. Shishkina
A certain danger is possessed by uranium compounds due to the high ability to accumulate in organs and tissues and to induce the oxidative stress. The soluble uranyl nitrate causes the oxidative damage the different biologically important compounds, including lipids. The aim of this work was to study the quantitative changes of the lipid composition in liver of mice CBA (males) and interrelations between the different parameters of the lipid peroxidation (LPO) in response to chronic γ-radiation at the dose of 16 cGy and presence of uranyl nitrate in drinking water at the concentration of 0,002 g/L under the separate and combined action of these factors. Mice were divided by four groups: I - control; II – a solution of uranil nitrate consumption during 30 days; II – the chronic γ-irradiation at the total dose of 1,6 cGy during 30 days; IV – the combined action of these factors during 30 days. The decapitation of mice was performed by early (during 1 day after action) and remote (during 30 day after action) period. In early period the more substantial changes between the quantitative ratio of PL fractions was revealed in the mice group III, and under the combined action of factors the increase the minor fractions and the decrease of phosphatidylcholine in liver PL were obtained. The reliable changes of the scale and character of interrelations between shares of the PL separate fraction and/or the generalized parameters of PL composition were revealed in all experimental groups both early and remote periods after actions. This should be taken into account when evaluating the effects of physical and chemical factors on animals inhabiting in ecologically unfavorable situations.