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Moskalev Alexey Alexandrovich
Moskalev Alexey Alexandrovich Doctor of biological sciences, PhD, Professor of Russian Academy of Sciences

Head of the Department of Ecology at Syktyvkar State University

Head of the Laboratory of Molecular Radiobiology and Gerontology of the
Institute of Biology, Komi Science Center of the Ural Division of the
Russian Academy of Science

Head of the Laboratory of Genetics of Aging and Longevity at MIPT (State University)


 
The main scientific and technical achievements:
A. Moskalev graduated from the Syktyvkar State University. He studied at the Department of Human and Animal Physiology of the Chemical-Biological Faculty. In 2001, A. Moskalev defended his PhD dissertation in speciality "Radiobiology" at the Lomonosov Moscow State University. At the same place, he defended a doctor of biological sciences dissertation in the area of radiobilogy.
Dr. Alexey Moskalev is working in the area of genetics of aging, focusing on the effect of low doze ionizing radiation on lifespan and aging of Drosophila strains with defects in apoptosis, DNA repair and defense genes. Specialist in the field of genetics of longevity and aging. He studies regulation mechanisms of the rate of aging, longevity and stress resistance in animal models (DNA repairation, heat shock proteins, NF-kB, Tor- and PI3K-signaling cascade, apoptosis). Geroprotective properties of PI3K, TOR, NF-kBHis inhibitors were identified in his works using fruit flies Drosophila as a model. Alexey participated in the work of identifying mechanisms of exceptional longevity of Myotis brandtii bats. He was a contributor in creating a database of biomarkers of aging Digital Ageing Atlas. Provides evidence for the hypothesis that low doze ionizing irradiation during early development led to selective elimination (by apoptosis) of weakened cells in several tissues that in turn delayed aging during the later stages of life. We also characterized the remote effects of low doze irradiation on mice (apoptosis, genetics instability, senescence, lifespan). Several years ago, we initiated studies on the role of DNA repair, epigenetic regulation, xenobiotic detoxification, and cytokines on lifespan using Drosophila as a model system. As a part of a group of authors sequenced the genome and transcriptome of smallest lived mammal - a Brandt's bat. My lab is supported by grants from the Russian Basic Research Foundation and Presidium of the Russian Academy of Sciences, and previously received support, in the form of three grants, from President of Russian Federation in the program that funded leading young scientists. I am a Vice-President of the Syktyvkar Branch of Russian Gerontology Society, President of Komi branch of Vavilov Society of Geneticists and Breeders, member of the editorial boards of Aging (Impact Journals), Biogerontology (Springer), Frontiers in Genetics of Aging (Nature Publishing Group), Aging and disease, Genes&Cells, SM Journal of Food and Nutritional Disorders (SM Journals). Co-chair of the International Symposiums “Genetics of Aging and Longevity” and “«Biomedical Innovation For Healthy Longevity»”.
He is the author of more than 100 publications in the area of ecological genetics and radiation ecology.

 
List of key publications:

Zainullin V.G., Moskalev A.A., Shaposhnikov M.V., Taskaev A.I. The modern aspects of Drosophila melanogaster radiobiology. Apoptosis and aging // Low doses of radiation: are they dangerous? / Ed. E.B. Burlakova — NY: Nova Science Publishers, Inc., 2000.— P. 61-75.

Moskalev A. Radiation-induced life span alteration of Drosophila lines with genotype differences // Biogerontology, 2007. – V. 8, N 5. – P. 499–504.
Moskalev A, Shaposhnikov M, Turysheva E. Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps // Biogerontology, 2009. - V. 10, N1. - P. 3-11.

Moskalev A.A., Shaposhnikov M.V. Pharmacological inhibition of phosphoinositide 3- and TOR-kinase improves survival of Drosophila melanogaster // Rejuvenation Res., 2010. – Vol. 13., N2-3. P. 246-247.

Plyusnina EN, Shaposhnikov MV, Moskalev AA. Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system // Biogerontology, 2011. – Vol. 12 , N 3. P. 211-226.

Moskalev AA, Plyusnina EN, Shaposhnikov MV. Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms // Biogerontology, 2011. – Vol. 12 , N 3. P. 253-263.

Moskalev A., Shaposhnikov M. Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster // Aging, 2011. Vol. 3. N4. P. 391-394.

Moskalev AA, Smit-McBride Z, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Tacutu R, Fraifeld VE. Gadd45 proteins: Relevance to aging, longevity and age-related pathologies. Ageing Res Rev, 2012. Vol. 11. N1. P.51-66.

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The Second International Conference "Genetics of Aging and Longevity" // Aging, 2012. Vol. 4. N5. P. 305-317.

Moskalev A, Plyusnina E, Shaposhnikov M, Shilova L, Kazachenok A, Zhavoronkov A. The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance // Cell Cycle. 2012. V. 11. N22. P. 4222 - 4241.

Zhavoronkov A, Smit-McBride Z, Guinan KJ, Litovchenko M, Moskalev A. Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases // J Mol Med (Berl). 2012. V. 90. N12. P. 1361-1389.
Shostal O.A., Moskalev A.A. The genetic mechanisms of the influence of the light regime on the lifespan of Drosophila melanogaster // Front Genet. 2012. N3. P. 325.
Moskalev AA, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Yanai H, Fraifeld VE. The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res Rev, 2013. Vol. 12. N2. P. 661–684.

Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y., Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Yim S.H., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N. Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii // Nature communications. — 2013. — V. 4. — DOI:10.1038/ncomms3212

Danilov A., Shaposhnikov M., Plyusnina E., Kogan V., Fedichev P., Moskalev A. Selective anticancer agents suppress aging in Drosophila // Oncotarget, 2013. Vol.4, No 9. P. 1527-1546.

Shaposhnikov M., Latkin D., Plyusnina E., Shilova L., Danilov A., Popov S., Zhavoronkov A., Ovodov Y., Moskalev A. The effects of pectins on life span and stress resistance in Drosophila melanogaster // Biogerontology, 2014. - Vol. 15, N2. - P.113-127. - DOI 10.1007/s10522-013-9484-x

Moskalev A, Shaposhnikov M, Snezhkina A, Kogan V, Plyusnina E, Peregudova D, Melnikova N, Uroshlev L, Mylnikov S, Dmitriev A, Plusnin S, Fedichev P, Kudryavtseva A. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation // PLoS One, 2014. Vol. 9, N1. - P.e86051. - doi: 10.1371/journal.pone.0086051.

Zhavoronkov A., Buzdin A.A., Garazha A.V., Borisov N.M., Moskalev A.A. Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs // Front. Genet., 2014. - Vol. 5, P. 1-6. - doi: 10.3389/fgene.2014.00049.

Moskalev A.A., Aliper A.M., Smit-McBride Z., Buzdin A., Zhavoronkov A. Genetics and epigenetics of aging and longevity // Cell Cycle, 2014. Vol. 13, N7. P. 1063 - 1077.

Moskalev AA, Pasyukova EG. From theories of aging to anti-aging interventions // Front Genet. 2014. V. 5. 276. doi: 10.3389/fgene.2014.00276

Bgatova N, Dubatolova T, Omelyanchuk L, Plyusnina E, Shaposhnikov M, Moskalev A. Gadd45 expression correlates with age dependent neurodegeneration in Drosophila melanogaster // Biogerontology, 2015. V. 16, N1, P. 53-61.

Craig T, Smelick C, Tacutu R, Wuttke D, Wood SH, Stanley H, Janssens G, Savitskaya E, Moskalev A, Arking R, de Magalhaes JP. The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource // Nucleic Acids Res. 2015. V. 43, N D1, Pp. D873-D878.

Moskalev A, Shaposhnikov M, Plyusnina E, Plyusnin S, Shostal O, Aliper A, Zhavoronkov A. Exhaustive data mining comparison of the effects of low doses of ionizing radiation, formaldehyde and dioxins // BMC Genomics, 2014 - V. 15, Suppl 12. - P. S5.

He C., Tsuchiyama S.K., Nguyen Q.T., Plyusnina E.N., Terrill S.R., Sahibzada S., Patel B., Faulkner A.R., Shaposhnikov M.V., Tian R., Tsuchiya M., Kaeberlein M., Moskalev A.A., Kennedy B.K., Polymenis M. Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import // PLoS genetics. 2014. Vol. 10, N 12. P. e1004860.

Aliper A.M., Csoka A.B., Buzdin A., Jetka T., Roumiantsev S., Moskalev A., Zhavoronkov A. Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells // Aging, 2015. - V. 7, N1. - P. 26-37.

Omelyanchuk LV, Shaposhnikov MV, Moskalev AA. Drosophila nervous system as a target of aging and anti-aging interventions // Front. Genet., 2015. V. 6. N89. doi: 10.3389/fgene.2015.00089

Velegzhaninov I, Mezenceva V, Shostal O, Baranova A, Moskalev A. Age dynamics of DNA damage and Cpg methylation in the peripheral blood leukocytes of mice // Mutation Research (Fundamental and Molecular Mechanisms of Mutagenesis), 2015. V. 775. P. 38-42.

Zhikrevetskaya S, Peregudova D, Danilov A, Plyusnina E, Krasnov G, Dmitriev A, Kudryavtseva A, Shaposhnikov M, Moskalev A. Effect of Low Doses (5-40 cGy) of Gamma-irradiation on Lifespan and Stress-related Genes Expression Profile in Drosophila melanogaster // PLoS One, 2015. Vol. 10, N. 8 - P. e0133840. - doi: 10.1371/journal.pone.0133840.

Proshkina EN, Shaposhnikov MV, Sadritdinova AF, Kudryavtseva AV, Moskalev AA. Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes // Ageing Res Rev, 2015. Vol. 24, Part B - P. 218-231, doi: 10.1016/j.arr.2015.08.005.
Danilov A, Shaposhnikov M, Shevchenko O, Zemskaya N, Zhavoronkov A, Moskalev A. Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity // Oncotarget, 2015. Vol. 6. N23. P.19428-19444.

Lashmanova E, Proshkina E, Zhikrivetskaya S, Shevchenko O, Marusich E, Leonov S, Melerzanov A, Zhavoronkov A, Moskalev A. Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans // Pharmacol Res, 2015. Vol. 100. P. 228-241. doi: 10.1016/j.phrs.2015.08.009

Moskalev A, Chernyagina E, de Magalhães JP, Barardo D, Thoppil H, Shaposhnikov M, Budovsky A, Fraifeld VE, Garazha A, Tsvetkov V, Bronovitsky E, Bogomolov V, Scerbacov A, Kuryan O, Gurinovich R, Jellen LC, Kennedy B, Mamoshina P, Dobrovolskaya E, Aliper A, Kaminsky D, Zhavoronkov A. Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease // Aging (Albany NY). 2015. Vol. 7, N9. P.616-628.

Shaposhnikov M, Proshkina E, Shilova L, Zhavoronkov A, Moskalev A. Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes // Sci Rep. 2015, Vol. 5. N 15299. doi: 10.1038/srep15299. P. 1-12.

Moskalev A., Zhikrivetskaya S., Krasnov G., Shaposhnikov M., Proshkina E., Borisoglebsky D., Danilov A., Peregudova D., Sharapova I., Dobrovolskaya E., Solovev I., Zemskaya N., Shilova L., Snezhkina A., Kudryavtseva A. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock // BMC Genomics 2015, 16(Suppl 13):S8 doi:10.1186/1471-2164-16-S13-S8.

Life Extension - Lessons from Drosophila /Vaiserman A, Moskalev A, Pasyukova E (Eds.), Springer, 2015, 353 p.

Tarrade S., Bhardwaj T., Flegal M., Bertrand L., Velegzhaninov I., Moskalev A., Klokov D. Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability // Int. J. Mol. Sci. 2015, Vol. 16, N12. P. 29996-30014; doi:10.3390/ijms161226216

Moskalev A., Zhikrivetskaya S., Shaposhnikov M., Dobrovolskaya E., Gurinovich R., Kuryan O., Pashuk A., Jellen L.C., Aliper A., Peregudov A., Zhavoronkov A. Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes // Nucleic Acids Res. 2016. Vol. 44, N D1. P. D894-D899.

Zhavoronkov A, Moskalev A. Editorial: Should We Treat Aging as a Disease? Academic, Pharmaceutical, Healthcare Policy, and Pension Fund Perspectives. Front Genet. 2016 Feb 16;7:17. doi: 10.3389/fgene.2016.00017.

Moskalev A, Chernyagina E, Tsvetkov V, Fedintsev A, Shaposhnikov M, Krut'ko V, Zhavoronkov A, Kennedy BK. Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell. 2016. Vol. 15. N3. P. 407-415. doi: 10.1111/acel.12463.

Putin E, Mamoshina P, Aliper A, Korzinkin M, Moskalev A, Kolosov A, Ostrovskiy A, Cantor C, Vijg J, Zhavoronkov A. Deep biomarkers of human aging: Application of deep neural networks to biomarker development. Aging (Albany NY). 2016 May 18.

Kudryavtseva AV, Krasnov GS, Dmitriev AA, Alekseev BY, Kardymon OL, Sadritdinova AF, Fedorova MS, Pokrovsky AV, Melnikova NV, Kaprin AD, Moskalev AA, Snezhkina AVю Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget. 2016 Jun 5. doi: 10.18632/oncotarget.9821.

Kudryavtseva AV, Lipatova AV, Zaretsky AR, Moskalev AA, Fedorova MS, Rasskazova AS, Shibukhova GA, Snezhkina AV, Kaprin AD, Alekseev BY, Dmitriev AA, Krasnov GS. Important molecular genetic markers of colorectal cancer. Oncotarget. 2016 Jun 2. doi: 10.18632/oncotarget.9796.

Pasyukova EG, Moskalev A. Editorial: Proceedings of the 3rd International Conference on Genetics of Aging and Longevity. Front Genet. 2016 Jun 24;7:119. doi: 10.3389/fgene.2016.00119.

Aliper A, Belikov AV, Garazha A, Jellen L, Artemov A, Suntsova M, Ivanova A, Venkova L, Borisov N, Buzdin A, Mamoshina P, Putin E, Swick AG, Moskalev A, Zhavoronkov A. In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state. Aging (Albany NY). 2016 Sep 24. doi: 10.18632/aging.101047.



Address: Institute of biology of Komi Science Center of Ural division of RAS.
167982, Syktyvkar
28 Kommunisticheskaja Str
Phone: 8 (8212) 31-28-94
e-mail: amoskalev@ib.komisc.ru

610000, Moskovskaya Str., 36,Kirov, Editing Department of the Journal “Theoretical and Applied Ecology”.
Phone/fax (8332) 37-02-77
e-mail: envjournal2017@gmail.com